Developmental Delay at the Single Cell Level in Prader-Willi Syndrome

Date: May 25, 2022

Time: 10:00 am Central

Prader-Willi Syndrome (PWS) is a neurodevelopmental disorder defined by a range of phenotypes including pronounced developmental delay, intellectual disability, sleep disorders and increased autism risk. Motor and language development is impaired in most PWS individuals and about 10-20% of PWS adults experience cycloid psychosis. The heterogeneity of the cognitive phenotypes in PWS warrant further study into the early neural development of PWS individuals.

In this informative webinar, Dr. Larry Reiter describes how his laboratory performed single cell RNA sequencing with the Parse Biosciences Evercode™

technology on neuronal cultures derived directly from dental pulp stem cells of individuals with PWS and neurotypical controls. Results suggest that

the PWS neurons display a delayed neurogenesis phenotype, at the single neuron level, that may explain the cognitive developmental delay in PWS and reveal potential therapeutic targets.

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