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Event Details

VCR Distinguished Lecture Series at Freeman Auditorium

Thursday, April 23, 2020

"Using Systems Approaches to Understand Disease"

Nevan Krogan, PhDProfessor, Department of Cellular and Molecular Pharmacology and Director, Quantitative Biosciences Institute, University of California-San Francisco

There is a wide gap between the generation of large-scale biological data sets and more-detailed, structural and mechanistic studies. However, recent work that explicitly combine data from systems and structural biological approaches is having a profound effect on our ability to predict how mutations and small molecules affect atomic-level mechanisms, disrupt systems-level networks and ultimately lead to changes in organismal fitness. Our group aims to create a stronger bridge between these areas primarily using three types of data: genetic interactions, protein-protein interactions and post-translational modifications.  Protein structural information helps to prioritize and functionally understand these large-scale datasets; conversely global, unbiasedly collected datasets helps inform the more mechanistic studies. Our efforts in this respect have been focused on model organisms, but more recently in mammalian cells, with a particular focus on cancer, psychiatric disorders and pathogenesis.

 

Dr. Nevan J. Krogan is a professor in the Department of Cellular and Molecular Pharmacology at the University of California-San Francisco (UCSF) as well as a senior investigator at the J. David Gladstone Institutes. He is also the Director of the Quantitative Biosciences Institute (QBI) at UCSF, which focuses on developing and using quantitative approaches to study basic biological mechanisms, often related to disease areas. Dr. Krogan's research is focused on using quantitative system approaches to help understand complex biological and biomedical problems, with a focus on infectious disease, cancer and psychiatric disorders. He serves as Director of The HARC Center, an NIH-funded collaborative group that focuses on the structural characterization of HIV-human protein complexes. Dr. Krogan is also the co-Director of three Cell Mapping initiatives, the Cancer Cell Mapping Initiative (CCMI), the Host Pathogen Map Initiative (HPMI) and the Psychiatric Cell Map Initiative (PCMI).  These initiatives map the gene and protein networks in healthy and diseased cells. These maps are now being used to better understand disease and provide novel therapies to fight them. He has authored over 250 papers in the fields of genetics and molecular biology and has given over 300 lectures and seminars nationally and internationally. He is a Searle Scholar, a Keck Distinguished Scholar and was recently awarded the Roddenberry Prize for Biomedical Research.
 

Venue Driving Directions venue weather venue information

Freeman Auditorium
930 Madison Avenue, 3rd Floor
Memphis TN 38163

Event Contact

Lee Ferguson

Phone: 9014482494
Website: Click to Visit
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